Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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3,946 – 3,960 of 4,590 results

3,946

Medchemexpress LLC Nα-Boc-Nω-nitro-D-arginine | 50913-12-7 | MFCD00038091 | 25g

Afatinib impurity 7 (Boc-D-Arg(NO2)-OH) is an impurity of Afatinib (HY-10261)

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3,947

Medchemexpress LLC 38-azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontan-1-amine | 2803478-25-1 | 98.0% | 614.73 g/mol | C26H54N4O12 | 25 MG

Azido-PEG12-amine is a PEG-based bifunctional linker with an azide at one terminus and a primary amine at the other. It functions as a water-soluble spacer (approximately 12 ethylene glycol units) used in click chemistry, bioconjugation, PROTAC and ADC linker design.

Azide and primary amine functional groups enable click chemistry and amide coupling.
Approximately 12 ethylene glycol units provide flexible, hydrophilic spacing.
Molecular weight 614.73 g/mol for predictable linker length and mass.
Purity 98.0% (NMR) as supplied in certificate of analysis.
Colorless to light yellow liquid physical form for ease of handling.
Stable when stored sealed and protected from moisture and light; in solvent: -80°C (6 months) or -20°C (1 month).

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3,948

Medchemexpress LLC Mocetinostat | 726169-73-9 | >98.0% | 200 MG

Mocetinostat is a benzamide histone deacetylase (HDAC) inhibitor selective for class I/IV HDACs, used as a research compound in epigenetics and oncology studies. Typical potency: HDAC1 0.15 μM; HDAC2 0.29 μM; HDAC3 1.66 μM; HDAC11 0.59 μM. For research use only.

Selective class I/IV HDAC inhibitor.
Used in epigenetics and cancer research.
Typical purity >98% (supplier dependent).
Molecular formula C23H20N6O; molecular weight ≈396.4 g/mol.
Supplied as a 200 mg research pack.

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3,949

eMolecules 819058-34-9 | 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | Ambeed | MFCD09033884 | 237.080 | C12H17BFNO2 | 97.000 | CC1(C)OB(OC1(C)C)c1ccc(N)c(F)c1 | 5g | 525043775

2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | Ambeed | 819058-34-9 | MFCD09033884 | 237.080 | C12H17BFNO2 | 97.000 | CC1(C)OB(OC1(C)C)c1ccc(N)c(F)c1 | 5g | 525043775

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3,950

Medchemexpress LLC 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline | 356559-20-1 | 100.0% | 200 MG

SB 525334 is a selective small-molecule inhibitor of transforming growth factor-β receptor I (ALK5) used in preclinical research to block TGF-β signaling. It exhibits potent enzymatic inhibition and is supplied as a solid reagent for laboratory use.

selective ALK5 inhibitor with IC50 = 14.3 nM
high purity suitable for research use
molecular formula C21H21N5 and molecular weight 343.42 g/mol
available as a 200 MG solid pack for dosing flexibility
stable under recommended storage conditions when stored as directed

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3,951

Medchemexpress LLC TLR7/8 agonist 1 dih 100mg | 1620278-72-9 | 100MG

TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline[1 [2

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3,952

Medchemexpress LLC 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid | 252916-29-3 | MFCD09743433 | >98.0% | 310.3 g/mol | C18H18N2O3 | 200 MG

Orantinib is a small-molecule, orally bioavailable receptor tyrosine kinase inhibitor that selectively inhibits VEGFR2, PDGFRβ, and FGFR1, blocking receptor autophosphorylation and angiogenesis. It is used in preclinical and clinical research for tumor growth inhibition and antiangiogenic studies. Chemical formula C18H18N2O3; molecular weight ~310.3 g/mol; CAS 252916-29-3.

Multi-target inhibition of VEGFR2, PDGFRβ, and FGFR1.
Orally bioavailable small molecule suitable for in vivo and in vitro studies.
Blocks receptor autophosphorylation and inhibits angiogenesis.
Applied in oncology and angiogenesis research applications.
High purity material appropriate for research use.

Pricing & Availability

3,953

Medchemexpress LLC TLR7/8 agonist 1 dihydrochloride | 1620278-72-9 | MFCD31657341; MFCD26793840 | 99.7% | 432.39 g/mol | C22H27Cl2N5 | 25 MG

TLR7/8 agonist 1 dihydrochloride is a TLR7/TLR8 dual-agonistic imidazoquinoline salt used as a research tool to activate innate immune signaling in cellular and animal studies. It is supplied as a high-purity solid suitable for in vitro and in vivo formulations.

High purity: 99.7%.
Molecular weight: 432.39 g/mol.
Chemical formula: C22H27Cl2N5.
Appearance: off-white to white solid.
Soluble in DMSO: 83.33 mg/mL (requires ultrasonic).
In vivo formulations: soluble ≥2.08 mg/mL in multiple vehicle systems.
Storage: 4°C sealed; in solvent -80°C (6 months) or -20°C (1 month).
Applications: TLR7/8 activation in immunology and pharmacology studies.

Pricing & Availability

3,954

Medchemexpress LLC Methotrexate metabolite | 19741-14-1 | MFCD00075774 | 98.4% | 325.33 g/mol | C15H15N7O2 | 200 MG

Methotrexate metabolite (DAMPA) is the primary active metabolite of methotrexate, supplied as an analytical standard for laboratory research, pharmacokinetic, and metabolism studies. It is intended for use as a reference standard in analytical assays and for investigation of methotrexate metabolism and clearance.

Active metabolite of methotrexate used as an analytical standard.
Suitable for pharmacokinetic and metabolism research.
Molecular formula C15H15N7O2.
Molecular weight 325.33 g/mol.
Purity 98.4% (HPLC).
Supplied as a solid for laboratory use.
Not for human or veterinary use.

Pricing & Availability

3,955

Medchemexpress LLC 1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride | 1620278-72-9 | MFCD31657341 | 99.7% | 432.39 g/mol | C22H27Cl2N5 | 1 ML

TLR7/8 agonist 1 dihydrochloride is a dual-agonistic imidazoquinoline research compound that activates toll-like receptors 7 and 8 to induce innate immune responses. It is used in cell-based assays and in vivo studies to stimulate immune signaling and can serve as a derivatizable precursor for covalent labeling while retaining biological activity.

Dual agonist of toll-like receptors 7 and 8, inducing innate immune signaling.
Low-nanomolar agonistic potency (≈50 nM for TLR7, ≈55 nM for TLR8).
Available as a DMSO solution for convenient dosing in cell assays.
Suitable for use in cell-based and in vivo immunostimulatory studies.
Precursor amenable to covalent modification without significant loss of activity.
Stable when stored sealed at 4°C; in solution recommended -80°C for long-term storage.

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3,956

Medchemexpress LLC Vk-II-86 (carvedilol analogue) | 955371-84-3 | 93.3% | 420.50 | C25H28N2O4 | 5 MG

VK-II-86 is a carvedilol analogue and a store-overload-induced calcium release (SOICR) inhibitor used as a research chemical to study cardiac arrhythmia mechanisms and calcium homeostasis. It lacks β-adrenoceptor antagonist activity and has been shown to prevent hypokalaemia-induced ventricular arrhythmia by normalizing ion channel activity and repolarization reserve.

Inhibits store-overload-induced calcium release, supporting arrhythmia research.
Lacks β-adrenoceptor antagonist activity, reducing β-blocking confounds in studies.
Reported to normalize calcium homeostasis and repolarization reserve in models.
Solid, light brown to brown appearance and supplied in small milligram quantities.
Molecular weight 420.50 g/mol; formula C25H28N2O4.
High purity (93.3%) suitable for laboratory research applications.

Pricing & Availability

3,957

Medchemexpress LLC LM11A-31 10mM 1mL | 102562-74-3 | 243.35 g/mol | C12H25N3O2 | 1 ML

LM11A-31 a non-peptide p75NTR (neurotrophin receptor p75) modulator is an orally active and potent proNGF (nerve growth factor) antagonist LM11A-31 is an amino acid derivative with high blood-brain barrier permeability and blocks p75-mediated cell death LM11A-31 reverses cholinergic neurite dystrophy in Alzheimer s disease mouse models with mid- to late-stage disease progression[1][2]

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3,958

Medchemexpress LLC Rgw-611 | 6497-78-5 | 98.0% | 226.24 | C9H14N4O3 | 10 MG

RGW-611 is a morpholine-derived research compound reported to enhance radiation-induced cell death in hypoxic V79-379A cells and to stimulate fatty acid synthesis. The compound is intended for laboratory research use and includes formulation, solubility, and storage guidance to support in vitro and in vivo preparation.

Enhances radiation-induced cell death in hypoxic V79-379A cells.
Stimulates fatty acid synthesis.
Chemical formula C9H14N4O3; molecular weight 226.24.
High DMSO solubility: 125 mg/mL with ultrasonic/warming to 60°C.
In vivo vehicle solubility ≥2.08 mg/mL reported for multiple formulations.
Storage: 4°C protected from light; in solvent -80°C (6 months) or -20°C (1 month).
Available in small research pack sizes with stock solution preparation volumes provided.

Pricing & Availability

3,959

Medchemexpress LLC 6-(2-(4-((4-fluorophenyl)phenylmethylidene)piperidin-1-yl)ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one | 93076-89-2 | MFCD00055114 | ≥98.0% | 459.58 g/mol | C27H26FN3OS | 25 MG

R 59-022 is a small-molecule research reagent that inhibits diacylglycerol kinase (DGK) and functions as a 5-HT receptor antagonist. It is used to modulate protein kinase C (PKC) activation and diacylglycerol-dependent signaling in biochemical and cell-based studies. Chemical identifiers include CAS 93076-89-2, formula C27H26FN3OS, and molecular weight ≈459.58 g/mol.

Potent DGK inhibitor (reported IC50 ≈ 2.8 μM).
Modulates PKC activation and diacylglycerol signaling.
Used in platelet aggregation and cellular signaling studies.
High reported purity (≥98%).
Provided in small research quantities suitable for assay development.

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3,960

Medchemexpress LLC B7-H2/ICOSLG Human 10ug

B7-H2/ICOSLG Protein Human (HEK293 His) is a polypeptide chain containing the C-termimal His tag produced in HEK293 cells ICOSLG is a number of the B7 family of co-stimulatory molecules

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Quinolines and derivatives

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Medchemexpress LLC Nα-Boc-Nω-nitro-D-arginine | 50913-12-7 | MFCD00038091 | 25g Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 38-azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontan-1-amine | 2803478-25-1 | 98.0% | 614.73 g/mol | C26H54N4O12 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Mocetinostat | 726169-73-9 | >98.0% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline | 356559-20-1 | 100.0% | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC TLR7/8 agonist 1 dih 100mg | 1620278-72-9 | 100MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC TLR7/8 agonist 1 dihydrochloride | 1620278-72-9 | MFCD31657341; MFCD26793840 | 99.7% | 432.39 g/mol | C22H27Cl2N5 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Methotrexate metabolite | 19741-14-1 | MFCD00075774 | 98.4% | 325.33 g/mol | C15H15N7O2 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride | 1620278-72-9 | MFCD31657341 | 99.7% | 432.39 g/mol | C22H27Cl2N5 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Vk-II-86 (carvedilol analogue) | 955371-84-3 | 93.3% | 420.50 | C25H28N2O4 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC LM11A-31 10mM 1mL | 102562-74-3 | 243.35 g/mol | C12H25N3O2 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Rgw-611 | 6497-78-5 | 98.0% | 226.24 | C9H14N4O3 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC B7-H2/ICOSLG Human 10ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More